原著論文
英文
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Violet Light Is Abundant Outdoors but Deficient Indoors in Modern Lifestyle in Tokyo
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Axial Length Shortened in Approximately 20% of Patients Wearing Extended Depth-of-Focus Contact Lenses
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Tropism of the AAV6.2 Vector in the Murine Retina
原著総説
英文
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Retinal ischemic diseases and promising therapeutic molecular targets
和文
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眼科分野における抗VEGF療法の変遷
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研究教育
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第128回 日本眼科学会総会 評議員会指名講演II 視覚とニューロサイエンス 光生物学を基盤とした眼疾患病態生理の理解と治療開発
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巳年に生まれて
原著論文
英文
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Acquisition of high-sensitivity human aqueous humor Raman spectra
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Deep Spectral Library of Mice Retina for Myopia Research: Proteomics Dataset generated by SWATH and DIA-NN
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Myopic shift in female mice after ovariectomy
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Fundus Image Analysis of Retinitis Pigmentosa Using Artificial Intelligence
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Choroidal thinning in myopia is associated with axial elongation and severity of myopic maculopathy
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Establishment of an in vitro choroid complex system for vascular response screening
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Inhibition of hypoxia-inducible factors suppresses subretinal fibrosis
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Deep learning segmentation of non-perfusion area from color fundus images and AI-generated fluorescein angiography
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Halofuginone prevents outer retinal degeneration in a mouse model of light-induced retinopathy
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Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1
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Slowing of Greater Axial Length Elongation Stemming from the COVID-19 Pandemic with Increasing Time Outdoors: The Tokyo Myopia Study
和文
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幼少期の強膜穿孔創から58年経過して外因性細菌性眼内炎を発症した1例
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抗血管内皮増殖因子薬療法を施行された滲出型加齢黄斑変性の病型別の長期視力変化
原著総説
英文
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Recent Insights into Roles of Hypoxia-Inducible Factors in Retinal Diseases
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Myopia Is an Ischemic Eye Condition: A Review from the Perspective of Choroidal Blood Flow
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Drusen in AMD from the Perspective of Cholesterol Metabolism and Hypoxic Response
和文
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近視進行抑制のエビデンス
原著論文
英文
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Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells
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Tight junction component protein claudin-1 deficiency in retinal pigment epithelium leads to early and intermediate age-related macular degeneration phenotypes in mice.
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Topical application of bunazosin hydrochloride suppresses myopia progression with an increase in choroidal blood perfusion
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Establishment of a novel ER-stress induced myopia model in mice
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Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina
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“Fruiting Liquid” of Mushroom-Forming Fungi, A Novel Source of Bioactive Compounds – Fruiting-Body Inducer and HIF and Axl Inhibitors
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Bisphenol A exposure triggers endoplasmic reticulum stress pathway leading to ocular axial elongation in mice
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Highly-sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice
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Identification of potential therapeutic targets for myopic choroidal neovascularization via discovery-driven data mining
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Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice
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Associations between fatty acid intake and diabetic retinopathy in a Japanese population
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The orientation of choroidal macrophage polarization significantly influences the development of myopia in murine models
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Encephalopsin (OPN3) is required for normal refractive development and the GO/GROW response to induced myopia
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Starburst amacrine cells amplify optogenetic visual restoration through gap junctions
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Myopia Is suppressed by digested lactoferrin or holo-lactoferrin administration
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Contralateral effect in progression and recovery of lens-induced myopia in mice
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Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice
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Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia
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Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration
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Association between fatty acid intakes and age-related macular degeneration in a Japanese population: JPHC-NEXT Eye Study
和文
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房水内代謝産物計測のためのレーザー透過機構とその安全性
原著総説
英文
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Pemafibrate, a potent selective peroxisome proliferator-activated receptor α modulator, a promising novel treatment for ischemic retinopathy?Lee D*, Tomita Y*, Negishi K, Kurihara T†
Neural Reg Res. 18(7) 1495–1496. Jul. 2023 -
Nicotinamide mononucleotide, a potential future therapy treatment in ocular diseases.Lee D, Tomita Y, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T†
Graefes Arch Clin Exp Ophthalmol. Jun. 2023 -
Therapeutic roles of PPARα activation in ocular ischemic diseasesLee D*, Tomita Y*, Negishi K, Kurihara T†
Histol Histopathol. 38(4) 391–401. Apr. 2023 -
Molecular and cellular regulations in the development of the choroidal circulation systemImanishi S, Tomita Y, Negishi K, Tsubota K†, Kurihara T†
Int J Mol Sci. 24(6) 5371. Mar. 2023
和文
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近視進行の分子細胞生物学的メカニズム栗原俊英
眼科 65(4) 359–365 2023年4月 -
近視進行の分子細胞生物学的メカニズム栗原俊英
眼科 65(4) 359–365 2023年4月 -
近視のトランスレーショナルリサーチ栗原俊英
Retina Medicine 12(1) 55-60 2023年4月
原著論文
英文
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Deep-learning-based AI for evaluating estimated nonperfusion areas requiring further examination in ultra-widefield fundus imagesInoda S, Takahashi H†, Yamagata H, Hisadome Y, Kondo Y, Tampo H, Sakamoto S, Katada Y, Kurihara T, Kawashima H, Yanagi Y
Sci Rep. 12(1):21826. Dec. 2022 -
Axl, Immune Checkpoint Molecules and HIF Inhibitors from the Culture Broth of Lepista luscinaKotajima M*, Choi JH*, Kondo M, D’Alessandro-Gabazza CN, Toda M, Yasuma T, Gabazza EC, Miwa Y, Shoda C, Lee D, Nakai A, Kurihara T, Wu J, Hirai H, Kawagishi H†
Molecules. 27(24) 8925-8925. Dec. 2022 -
Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery OcclusionLee D, Tomita Y, Miwa Y, Jeong H, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T†
Intl J Mol Sci. 23(23) 14711. Nov. 2022 -
Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical TrialTorii H*†, Mori K*, Takashi Okano T, Kondo S, Yang HY, Yotsukura E, Hanyuda A, Ogawa M, Negishi K, Kurihara T†, Tsubota K†
J Clin Med. 11(20) 6000. Oct. 2022 -
Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyesIkeda SI, Kurihara T†, Jiang X, Miwa Y, Lee D, Serizawa N, Jeong H, Mori K, Katada Y, Kunimi H, Ozawa N, Shoda C, Ibuki M, Negishi K, Torii H, Tsubota K†
Nat Commun. 13(1):5859. Oct. 2022 -
Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia/Reperfusion InjuryLee D, Tomita Y, Miwa Y, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T†
Int J Mol Sci. 23(19) 11228. Sep. 2022 -
Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenanceZhang Y*, Jeong H*, Mori K, Ikeda SI, Shoda C, Miwa Y, Nakai A, Chen J, Ma Z, Jiang X, Torii H, Kubota Y, Negishi K, Kurihara T†, Tsubota K†
PNAS Nexus. pgac166. Aug. 2022 -
Automatic segmentation of non-perfusion area from fluorescein angiography using deep learning with uncertainty estimationMasayoshi K*, Katada Y*, Ozawa N, Ibuki M, Negishi K, Kurihara T†
Inform Med Unlocked. 101060-101060. Aug. 2022 -
Retinal degeneration induced in a mouse model of ischemia–reperfusion injury and its management by pemafibrate treatmentLee D, Nakai A, Miwa Y, Tomita Y, Kunimi H, Chen J, Ikeda SI, Tsubota K, Negishi K, Kurihara T†
FASEB J. 36(9):e22497. Aug. 2022 -
Children in Tokyo Have a Long Sustained Axial Length from Age 3 Years: The Tokyo Myopia Study.Maruyama T*, Yotsukura E*, Torii H*†, Mori K, Inokuchi M, Tokumura M, Hazra D, Ogawa M, Hanyuda A, Tsubota K, Kurihara T†, Negishi K†
J Clin Med. 11(15) 4413. Jul. 2022 -
Relation between Dry Eye and Myopia Based on Tear Film Breakup Time, Higher Order Aberration, Choroidal Thickness, and Axial Length.Hazra D*, Yotsukura E*, Torii H*†, Mori K, Maruyama T, Ogawa M, Hanyuda A, Tsubota K, Kurihara T†, Negishi K†
Sci Rep. 12(8) 10891. Jun. 2022 -
Lipidomic analysis revealed n‐3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice.Mori K*, Kuroha S*, Hou J, Jeong H, Ogawa M, Ikeda SI, Kang JX, Negishi K, Torii H, Arita M†, Kurihara T†, Tsubota K
FASEB J. 36(6) e22312. May. 2022 -
Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy.Ofuji Y*, Katada Y*, Tomita Y, Nagai N, Sonobe H, Watanabe K, Shinoda H, Ozawa Y, Negishi K, Tsubota K, Kurihara T†
Life. 12(4):542. Apr. 2022 -
Relationship of choroidal thickness and axial length with posterior vitreous detachment in patients with high myopiaHanyuda A*, Torii H*, Hayashi K, Uchida A, Mori K, Yotsukura E, Ogawa M, Negishi K, Kurihara T†, Tsubota T†
Sci Rep. 12(1):4093. Mar. 2022
原著総説
英文
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Multiple Factors Causing Myopia and the Possible Treatments: A Mini Review.Shinojima A, Negishi K, Tsubota K, Kurihara T†
Front Public Health. 10:897600. May. 2022 -
Ocular Ischemic Syndrome and Its Related Experimental Models.Lee D*, Tomita Y*, Yang L, Negishi K, Kurihara T†
Int J Mol Sci. (9) 5249-5249. May. 2022 -
Degeneration of retinal ganglion cells in hypoxic responses: hypoxia-inducible factor inhibition, a new therapeutic insight.Lee D, Kunimi H, Negishi K, Kurihara T†
Neural Regen Res. 17(10) 2730-2731. Feb. 2022
和文
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今月のサイエンス(5)栗原俊英
慶應医学部新聞 -
注目のイチオシ論文 : やさしく解説(第21回)オプトジェネティクスを応用した治療による視機能の部分的回復栗原俊英
Retina Medicine 11(2) 145-148 2022年10月 -
学童近視進行予防の現状栗原俊英
医療情報誌アニムス (110) 11-16 2022年4月
原著論文
英文
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Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion.Lee D, Nakai A, Miwa Y, Tomita Y, Serizawa N, Katada Y, Hatanaka Y, Tsubota K, Negishi K, Kurihara T†
Biomed Res Int. 2021:7727648. Dec. 2021 -
Effect of Violet Light-Transmitting Eyeglasses on Axial Elongation in Myopic Children: A Randomized Controlled Trial.Mori K*, Torii H*, Hara Y, Hara M, Yotsukura E, Hanyuda A, Negishi K, Kurihara T†, Tsubota K†
J Clin Med. 10(22):5462. Nov. 2021 -
Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.Kurihara T*†, Lee D*, Shinojima A*, Kinoshita T, Nishizaki S, Arita Y, Hidaka Y, Nishi Y, Shirakawa Y, Kimura S, Tsuneyoshi Y, Torii H, Tsubota K, Negishi K†
PLOS ONE. 16(9):e0256986. Sep. 2021 -
Shorter Axial Length Is a Risk Factor for Proliferative Vitreoretinopathy Grade C in Eyes Unmodified by Surgical Invasion.Minami S, Uchida A, Nagai N, Shinoda H, Kurihara T, Ban N, Terasaki H, Takagi H, Tsubota K, Sakamoto T, Ozawa Y†
J Clin Med. 10(17):3944. Aug. 2021 -
Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion.Lee D*, Tomita Y*, Jeong H, Miwa Y, Tsubota K, Negishi K, Kurihara T†
Int J Mol Sci. 22(17):9408-9408. Aug. 2021 -
Association between ocular axial length and anthropometrics of Asian adults.Shinojima A, Kurihara T†, Mori K, Iwai Y, Hanyuda A, Negishi K, Torii H, Tsubota K*
BMC Res Notes. 14(1):328-328. Aug. 2021 -
Inhibition of the HIF-1α/BNIP3 pathway has a retinal neuroprotective effect.Kunimi H, Lee D, Ibuki M, Katada Y, Negishi K, Tsubota K, Kurihara T†.
FASEB J. 35(8):e21829. Aug. 2021 -
Retinal dysfunction induced in a mouse model of unilateral common carotid artery occlusion.Lee D*, Jeong H*, Miwa Y, Shinojima A, Katada Y, Tsubota K†, Kurihara T†
PeerJ. 9:e11665. Jun. 2021 -
Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report.Ozawa H, Usui Y, Takano Y, Horiuchi N, Kuribayashi T, Kurihara T, Smith LEH, Tsubota K†, Tomita Y†
Medicine. 100(22):e26232. Jun. 2021 -
Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.Jiang X*, Pardue MT*, Mori K, Ikeda SI, Torii H, D’Souza S, Lang RA, Kurihara T†, Tsubota K†
Proc Natl Acad Sci U S A. 118(22):e2018840118. Jun. 2021 -
Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study.Hieda O, Hiraoka T, Fujikado T, Ishiko S, Hasebe S, Torii H, Takahashi H, Nakamura Y, Sotozono C, Oshika T, Morimoto T, Nishida K, Nishikawa N, Song YS, Tokutake T, Nishi Y, Shigeno Y, Kurihara T, Negishi K, Tsubota K, Ono M, Nakai T, Tan D, Tanaka S, Kinoshita S†,
Jpn J Ophthalmol. 65(3):315-325. May. 2021 -
Long-term follow-up of a Chinese patient with KCNV2-retinopathy.Lie H*, Wang G*, Liu X*, Meng X, Long Y, Ren J, Yang L, Fujinami-Yokokawa Y, Kurihara T, Tsubota K, Fujinami K†, Li S†
Ophthalmic Genet. 42(2):144-149. Apr. 2021 -
Assessment of Hypofluorescent Foci on Late-Phase Indocyanine Green Angiography in Central Serous Chorioretinopathy.Shinojima A*†, Ozawa Y*†, Uchida A, Nagai N, Shinoda H, Kurihara T, Suzuki M, Minami S, Negishi K, Tsubota K
J. Clin. Med. 10(10):2178. May. 2021 -
Fenofibrate Protects against Retinal Dysfunction in a Murine Model of Common Carotid Artery Occlusion-Induced Ocular Ischemia.Lee D*, Tomita Y*, Miwa Y, Jeong H, Mori K, Tsubota K†, Kurihara T†
Pharmaceuticals. 14(3):223 Mar. 2021 -
Spatial Functional Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.2.Yang L*, Joo K *, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Pontikos N, Liu X, Nakamura N, Kurihara T, Tsubota K, Iwata T, Li H, Zou X, Wu S, Sun Z, Ahn SJ, Kim MS, Mun YS, Park KH, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K†
Am J Ophthalmol. 221:169-180. Jan. 2021
原著総説
英文
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Retinal Diseases Regulated by Hypoxia-Basic and Clinical Perspectives: A Comprehensive Review.Shinojima A, Lee D, Tsubota K, Negishi K, Kurihara T†
J Clin Med. 10(23) 5496. Nov. 2021 -
PPARα Modulation-Based Therapy in Central Nervous System Diseases.Lee D*, Tomita Y*, Allen W, Tsubota K, Negishi K, Kurihara T†
Life. 11(11). Nov. 2021 -
Updates on the Current Treatments for Diabetic Retinopathy and Possibility of Future Oral Therapy.Tomita Y*, Lee D*, Tsubota K, Negishi K, Kurihara T†
J Clin Med. 10(20) 4666. Oct. 2021 -
HIF Inhibition Therapy in Ocular Diseases.Lee D*, Miwa Y*, Kunimi H, Ibuki M, Shoda C, Nakai A, Kurihara T†
Keio J Med. Apr. 2021
和文
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目の働きはものを「見る」だけではない坪田一男、鳥居秀成、栗原俊英
BRAIN and NERVE 73(11) 1185-1191 2021年11月 -
糖尿病網膜症進展に関わる低酸素応答とその制御栗原俊英
糖尿病合併症 35(2) 203 2021年8月 -
低酸素応答制御に基づく網膜視神経疾患への創薬栗原俊英
眼薬理 35(1) 59-62 2021年8月 -
今月のサイエンス(4)栗原俊英
慶應医学部新聞 -
オプトジェネティクスによる網膜変性疾患の視覚再建栗原俊英
眼科臨床紀要 14(7) 421-423 2021年7月 -
網膜橋渡し研究アップデート 11.光遺伝学療法栗原俊英
眼科 63(2) 162-166 2021年2月 -
基礎研究コラム44. 選択的PPARα作動薬の網膜疾患への有用性富田洋平、栗原俊英
あたらしい眼科 38(1) 81 2021年1月 -
屋外環境光による介入栗原俊英
眼科 63(1): 17-22 2021年1月
原著論文
英文
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Axial Length and Prevalence of Myopia among Schoolchildren in the Equatorial Region of Brazil.
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Axial length shortening in a myopic child with anisometropic amblyopia after wearing violet light-transmitting eyeglasses for 2 years.
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Automatic screening for diabetic retinopathy in interracial fundus images using artificial intelligence.
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Oral Bovine Milk Lactoferrin Administration Suppressed Myopia Development through Matrix Metalloproteinase 2 in a Mouse Model.
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Efficacy of the Newly Invented Eyelid Clamper in Ultra-Widefield Fundus Imaging.
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Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors.
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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion.
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Association between axial length and choroidal thickness in early age-related macular degeneration.
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Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane.
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A Fairy Chemical Suppresses Retinal Angiogenesis as a HIF Inhibitor.
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RP2-associated retinal disorder in a Japanese cohort:Report of novel variants and a literature review, identifying a genotype–phenotype association.
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Clinical and genetic characteristics of Stargardt disease in a large Western China cohort: Report 1.
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Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population.
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Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy.
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Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome.
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Retinal microglia are critical for subretinal neovascular formation.
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Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association.
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Clinical and Genetic Characteristics of 15 Affected Patients From 12 Japanese Families with
GUCY2D -Associated Retinal Disorder. -
The Area and Number of Intraretinal Cystoid Spaces Predict the Visual Outcome after Ranibizumab Monotherapy in Diabetic Macular Edema.
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Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration.
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Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy.
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Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.
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Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina.
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Closure of macular hole secondary to ischemic hemi-central retinal vein occlusion by retinal photocoagulation and topical anti-inflammatory treatment.
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Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization.
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Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study.
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Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice.
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Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy.
原著総説
英文
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PPARα Agonist Oral Therapy in Diabetic Retinopathy.
和文
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ブルーライトとスマートフォン
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クロセチンの眼疾患に対する進行予防効果
原著論文
英文
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Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy.
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Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults.
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The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects.
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Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models.
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Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model.
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Effect of midazolam, medetomidine, and butorphanol tartrate combination anesthetic on electroretinograms of mice.
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High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study.
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Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration.
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HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model.
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Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake Disease) East Asia Occult Macular Dystrophy Studies Report Number 1.
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The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia.
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Pharmacological HIF inhibition prevents retinal neovascularization with improved visual function in a murine oxygen-induced retinopathy model.
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Ultra-Widefield Retinal Imaging for Analyzing the Association Between Types of Pathological Myopia and Posterior Staphyloma.
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Current Prevalence of Myopia and Association of Myopia With Environmental Factors Among Schoolchildren in Japan.
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The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial.
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Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy.
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Ocular-Component-Specific miRNA Expression in a Murine Model of Lens-Induced Myopia.
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A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion.
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Inducement and Evaluation of a Murine Model of Experimental Myopia.
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QD laser eyewear as a visual field aid in a visual field defect model.
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Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia.
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Evaluation of AAV-DJ vector for retinal gene therapy.
和文
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組織型プラスミノーゲンアクチベーター(tPA;モンテプラーゼ)硝子体内投与による黄斑下血腫の治療経過
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造血幹細胞移植後の新規ドライアイ発症例に近視化を伴った3症例
原著総説
和文
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網膜疾患に対する遺伝子治療の現状と今後の可能性
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【医療×新ビジネス】《どこまで進む!?新技術の医療導入》
大学発ベンチャーの挑戦 -CSV経営により社会の応援を得られるベンチャーをめざす- -
近視発生、進行の基礎概念
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近視のマウスモデル研究とこれまでの動物モデル研究
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これからの近視抑制研究の方向性
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近視抑える「眼鏡・食品・コンタクト」の最新研究
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「1日2時間屋外活動」と目薬が近視を抑える可能性
原著論文
英文
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Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina.
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A highly efficient murine model of experimental myopia.
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Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline.
原著総説
英文
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Progress and Control of Myopia by Light Environments.
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Roles of hypoxia response in retinal development and pathophysiology
和文
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子どもの失明原因1位、増える「未熟児網膜症」
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網膜橋渡し研究アップデート:1.分子標的薬(抗血管新生療法)
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視覚障害の原因2位、難病「網膜色素変性」とは
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あなたは大丈夫?失明の危険もある「病的近視」とは
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突然の視力低下や視野障害 網膜血管閉塞症とは
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紫色と近視と
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剥がれた網膜を戻す 治療最前線
原著論文
英文
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Elevated Aqueous Cytokine Levels in Eyes With Ocular Surface Diseases.
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Violet Light Transmission is Related to Myopia Progression in Adult High Myopia.
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Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration.
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Predictive factors of better outcomes by monotherapy of an antivascular endothelial growth factor drug, ranibizumab, for diabetic macular edema in clinical practice.
原著総説
和文
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低酸素応答 どうして新生血管は発生するのか 基礎研究コラム⑦
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稲光やちりが見え、視野が狭まる…目に何が?
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JRPSもうまく基金賞 2016年度受賞者研究結果報告
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「VEGFの網膜における生理的重要性」抗VEGF治療セミナー:46
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自覚症状なく進行 危険な糖尿病網膜症
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【近視の進行をコントロールする】屋外環境とのかかわり
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国内の失明原因4位 加齢黄斑変性とは
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“目の毒”と日々闘う網膜の仕組み
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眼疾患とエピジェネティクス
原著論文
英文
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Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment.
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Distinct responsiveness to intravitreal ranibizumab therapy in polypoidal choroidal vasculopathy with single or multiple polyps.
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Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.
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Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression.
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The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation.
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iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study
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Global metabolomics reveals metabolic dysregulation in ischemic retinopathy.
和文
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ルテイン高含有ホウレンソウ摂取による黄斑色素密度に対する効果のパイロットスタディ
原著総説
英文
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Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina
和文
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アンチエイジング研究の最前線
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『小児眼科Q&A』 I 学童近視、近視検査、屈折異常など. 14. 実験近視モデルの種類と特徴を教えてください
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2016年度研究助成<もうまく基金賞>を受賞して
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JRPSもうまく基金賞 2016年度研究助成受賞者実施計画
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北里賞を受賞して
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網膜光毒性:現状評価と課題
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生涯学習のための眼科医レベルチェックテスト 「網膜硝子体疾患」
原著論文
英文
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Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling.
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Neurovascular crosstalk between interneurons and capillaries is required for vision.
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Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo.
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Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension.
原著総説
和文
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注目のイチオシ論文:やさしく解説(第7回)網膜において神経細胞はVEGF量を規定することにより血管新生を制限する
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三四会奨励賞を受賞して
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低酸素に制御される網膜 ―発生から病態生理まで―
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第一次硝子体過形成遺残(PHPV)