Achievements

原著論文

英文

  • Violet Light Is Abundant Outdoors but Deficient Indoors in Modern Lifestyle in Tokyo
    Kondo S*, Jiang X*, Torii H, Mori K, Negishi K, Kurihara T†, Tsubota K†
    Int J Enviro Res Public Health. 22(3) 444-444. Mar. 2025
  • Axial Length Shortened in Approximately 20% of Patients Wearing Extended Depth-of-Focus Contact Lenses
    Hazra D*, Yotsukura E*, Oyama S*, Shigeno Y, Mori K, Takeuchi R, Nakajima Y, Hanyuda A, Ogawa M, Kurihara T, Torii H†, Negishi K†
    J Clin Med. 14(5) 1750. Mar. 2025
  • Tropism of the AAV6.2 Vector in the Murine Retina
    Suzuki R*, Katada Y*, Fujii M, Serizawa N, Negishi K, Kurihara T†
    Int J Mol Sci. 26(4) 1580. Feb. 2025

原著総説

英文

  • Retinal ischemic diseases and promising therapeutic molecular targets
    Lee D*, Tomita Y*, Negishi K, Kurihara T†
    Histol Histopathol. 40 11-20 Jan. 2025

和文

  • 眼科分野における抗VEGF療法の変遷
    栗原俊英
    IOL&RS39(1) 96-101 2025年3月25日
  • 研究教育
    栗原俊英
    日本の眼科 96(3) 266-270 2025年3月20日
  • 第128回 日本眼科学会総会 評議員会指名講演II 視覚とニューロサイエンス 光生物学を基盤とした眼疾患病態生理の理解と治療開発
    栗原俊英
    日眼会誌 129(3) 354-378 2025年3月10日
  • 巳年に生まれて
    栗原俊英
    日本の眼科 96(1) 8 2025年1月

原著論文

英文

  • Acquisition of high-sensitivity human aqueous humor Raman spectra
    Shinojima A, Sawada M, Kuroda M, Lee D, Kinoshita T, Negishi K, Kurihara T†
    Res Sq. Oct. 2024 (未査読)
  • Deep Spectral Library of Mice Retina for Myopia Research: Proteomics Dataset generated by SWATH and DIA-NN
    Sze YH, Tse DYY, Zuo B, Li KK, Zhao Q, Jiang X, Kurihara T, Tsubota K, Lam TC†
    Sci Data. 11(1) 1115-1115 Oct. 2024
  • Myopic shift in female mice after ovariectomy
    Zhang Y, Mori K, Jeong H, Chen J, Liang Y, Negishi K, Tsubota K†, Kurihara T†
    Sci Rep. 14(1) 22946-22946 Oct. 2024
  • Fundus Image Analysis of Retinitis Pigmentosa Using Artificial Intelligence
    Ubukata S*, Masayoshi K*, Katada Y†, Yang L, Ozawa N, Ibuki M, Negishi K, Kurihara T†
    Res Sq. Sep. 2024 (未査読)
  • Choroidal thinning in myopia is associated with axial elongation and severity of myopic maculopathy
    Midorikawa M*, Mori K*, Torii H, Tomita Y, Zhang Y, Tsubota K†, Kurihara T†, Negishi K†
    Sci Rep. 14(1) 17600 Jul. 2024
  • Establishment of an in vitro choroid complex system for vascular response screening
    Jeong H, Lee D, Negishi K, Tsubota K†, Kurihara T†
    Sci Rep. 14 16129 Jul. 2024
  • Inhibition of hypoxia-inducible factors suppresses subretinal fibrosis
    Shoda C*, Lee D*, Miwa Y, Yamagami S, Nakashizuka H, Nimura K, Okamoto K, Kawagishi H, Negishi K, Kurihara T†
    FASEB J. 38(13) e23792 Jul. 2024
  • Deep learning segmentation of non-perfusion area from color fundus images and AI-generated fluorescein angiography
    Masayoshi K*, Katada Y*, Ozawa N, Ibuki M, Negishi K, Kurihara T†
    Sci Rep.14 10801 May. 2024
  • Halofuginone prevents outer retinal degeneration in a mouse model of light-induced retinopathy
    Miwa Y*, Lee D*, Shoda C, Jeong H, Negishi K, Kurihara T†
    PLOS ONE. 19(3) e0300045 May. 2024
  • Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1
    Chen J*, Ikeda SI*, Yang Y, Zhang Y, Ma Z, Liang Y, Negishi K, Tsubota K†, Kurihara T†
    Mol Med. 30 25. Feb. 2024
  • Slowing of Greater Axial Length Elongation Stemming from the COVID-19 Pandemic with Increasing Time Outdoors: The Tokyo Myopia Study
    Yotsukura E, Torii H†, Mori K, Ogawa M, Hanyuda A, Negishi K, Kurihara T†, Tsubota K†
    Ophthalmol Sci. 100491-100491. Feb. 2024

和文

  • 幼少期の強膜穿孔創から58年経過して外因性細菌性眼内炎を発症した1例
    上村綾音、伴紀充、國見洋光、富田洋平、栗原俊英、篠田 肇、根岸一乃
    眼科臨床紀要 17(10) 749-752 2024年12月
  • 抗血管内皮増殖因子薬療法を施行された滲出型加齢黄斑変性の病型別の長期視力変化
    加藤想史、内田敦郎†、永井紀博、鈴木美砂、南早紀子、篠島亜里、伴紀充、堀内直樹、藤岡俊平、栗原俊英、篠田肇、小沢洋子、根岸一乃
    日本眼科学会雑誌 128(6) 473-486 2024年6月

原著総説

英文

  • Recent Insights into Roles of Hypoxia-Inducible Factors in Retinal Diseases
    Lee D, Tomita Y, Miwa Y, Kunimi H, Nakai A, Shoda C, Negishi K, Kurihara T†
    Int J Mol Sci. 25 10140 Sep. 2024
  • Myopia Is an Ischemic Eye Condition: A Review from the Perspective of Choroidal Blood Flow
    Baksh J*, Lee D*, Mori K, Zhang Y, Torii H, Jeong H, Hou J, Negishi K, Tsubota K†, Kurihara T†
    J Clin Med. 13(10) 2777-2777 May. 2024
  • Drusen in AMD from the Perspective of Cholesterol Metabolism and Hypoxic Response
    Ban N, Shinojima A, Negishi K, Kurihara T†
    J Clin Med. 13(9) 2608 Apr. 2024

和文

  • 近視進行抑制のエビデンス
    森紀和子、栗原俊英
    あたらしい眼科41(4) 375-385 2024年4月

原著論文

英文

  • Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells
    Nakai A, Lee D, Shoda C, Negishi K, Nakashizuka H, Yamagami S, Kurihara T†
    J Ophthalmol. 2023 6617981. Dec. 2023
  • Tight junction component protein claudin-1 deficiency in retinal pigment epithelium leads to early and intermediate age-related macular degeneration phenotypes in mice.
    Nakai A, Lee D, Zhang Y, Shoda C, Imanishi S, Jeong H, Ikeda SI, Negishi K, Nakashizuka H, Yamagami S. Kubo A. Kurihara T†
    bioRxiv. 570525. Dec. 2023 (未査読)
  • Topical application of bunazosin hydrochloride suppresses myopia progression with an increase in choroidal blood perfusion
    Jeong H, Lee D, Jiang X, Negishi K, Tsubota K†, Kurihara T†
    Invest Ophthalmol Vis Sci. 64(14):15. Nov. 2023
  • Establishment of a novel ER-stress induced myopia model in mice
    Kang L, Ikeda SI, Yang Y, Jeong H, Chen J, Zhang Y, Negishi K, Tsubota K†, Kurihara T†
    Eye Vis. 10(1):44. Nov. 2023
  • Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina
    Jeong H, Lee D, Jiang X, Negishi K, Tsubota K†, Kurihara T†
    Sci Rep. 13(1):17861. Oct. 2023
  • “Fruiting Liquid” of Mushroom-Forming Fungi, A Novel Source of Bioactive Compounds – Fruiting-Body Inducer and HIF and Axl Inhibitors
    Wu J, Uchida K, Yoshikawa A, Hashimoto M, Kondo M, Nihei K, Ishii M, Choi JH, Miwa Y, Shoda C, Lee D, Nakai A, Kurihara T, D’Alessandro-Gabazza CN, Toda M, Yasuma T, Gabazza EC, Hirai H, Kawagishi H†
    J Agric Food Chem. 71(36):13338-13345. Aug. 2023
  • Bisphenol A exposure triggers endoplasmic reticulum stress pathway leading to ocular axial elongation in mice
    Chen J*, Ikeda SI*, Kang L, Negishi K, Tsubota K†, Kurihara T†
    Front Med. 10:1255121. Aug. 2023
  • Highly-sensitive visual restoration and protection via ectopic expression of chimeric rhodopsin in mice
    Katada Y, Yoshida K, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tsubota K, Kurihara T†
    iScience. 26(10):107716. Aug. 2023
  • Identification of potential therapeutic targets for myopic choroidal neovascularization via discovery-driven data mining
    Chen J, Ikeda SI, Negishi K, Tsubota K†, Kurihara T†
    Curr Eye Res. 29:1-10. Aug. 2023
  • Long chain acyl-CoA synthetase 6 facilitates the local distribution of di-docosahexaenoic acid- and ultra-long-chain-PUFA-containing phospholipids in the retina to support normal visual function in mice
    Kuroha S, Katada Y, Isobe Y, Uchino H, Shishikura K, Nirasawa T, Tsubota K, Negishi K, Kurihara T†, Arita M†
    FASEB J. 37(9) e23151. Aug. 2023
  • Associations between fatty acid intake and diabetic retinopathy in a Japanese population
    Sasaki M†, Yuki K, Hanyuda A, Yamagishi K†, Motomura K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Sawada N, Negishi K, Tsubota K, Tsugane S, Iso H
    Sci Rep. 13(1) 12903. Aug. 2023
  • The orientation of choroidal macrophage polarization significantly influences the development of myopia in murine models
    Hou J*, Ikeda SI*, Mori K, Jeong H, Torii H, Negishi K, Tsubota K†, Kurihara T†
    bioRxiv. Jun. 2023 (未査読)
  • Encephalopsin (OPN3) is required for normal refractive development and the GO/GROW response to induced myopia
    Linne C, Mon KY, D’Souza S, Jeong H, Jiang X, Brown DM, Zhang K, Vemaraju S, Tsubota K, Kurihara T, Pardue MT, Lang RA†
    Mol Vis. 29:39-57. May. 2023
  • Starburst amacrine cells amplify optogenetic visual restoration through gap junctions
    Katada Y, Kunimi H, Serizawa N, Lee D, Kobayashi K, Negishi K, Okano H, Tanaka KF, Tsubota K, Kurihara T†
    Mol Ther Methods Clin Dev. 30:1-13. May. 2023
  • Myopia Is suppressed by digested lactoferrin or holo-lactoferrin administration
    Liang Y, Ikeda SI, Chen J, Zhang Y, Negishi K, Tsubota K†, Kurihara T†
    Int J Mol Sci. 24(6) 5815. Mar. 2023
  • Contralateral effect in progression and recovery of lens-induced myopia in mice
    Ma Z*, Jeong H*, Yang Y, Jiang X, Ikeda SI, Negishi K, Kurihara T†, Tsubota K†
    Ophthal Physiol Opt. 43(3):558-565. Mar. 2023
  • Ginkgo biloba extracts improve choroidal circulation leading to suppression of myopia in mice
    Hou J*, Mori K*, Ikeda SI, Jeong H, Torii H, Negishi K, Kurihara T†, Tsubota K†
    Sci Rep. 13(1):3772. Mar. 2023
  • Suppressive effects of violet light transmission on myopia progression in a mouse model of lens-induced myopia
    Jeong H, Kurihara T†, Jiang X, Kondo S, Ueno Y, Hayashi Y, Lee D, Ikeda SI, Mori K, Torii H, Negishi K, Tsubota K†
    Exp Eye Res. 228:109414. Feb. 2023
  • Pemafibrate prevents choroidal neovascularization in a mouse model of neovascular age-related macular degeneration
    Lee D, Nakai A, Miwa Y, Negishi K, Tomita Y, Kurihara T†
    PeerJ. 11:e14611. Jan. 2023
  • Association between fatty acid intakes and age-related macular degeneration in a Japanese population: JPHC-NEXT Eye Study
    Yasukawa T*, Sasaki M*†, Motomura K, Yuki K, Kurihara T, Tomita Y, Mori K, Ozawa N, Ozawa Y, Yamagishi K†, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H
    Transl Vis Sci Technol. 12(1) 3. Jan. 2023

和文

  • 房水内代謝産物計測のためのレーザー透過機構とその安全性
    栗原俊英、篠島亜里、木下卓、西崎早織、白川佳則、木村翔、李德鎬、日高悠葵、西恭代、常吉 由佳里、鳥居秀成、坪田一男、根岸一乃
    日本眼科学会雑誌 127(7) 672-679 2023年7月

原著総説

英文

  • Pemafibrate, a potent selective peroxisome proliferator-activated receptor α modulator, a promising novel treatment for ischemic retinopathy?
    Lee D*, Tomita Y*, Negishi K, Kurihara T†
    Neural Reg Res. 18(7) 1495–1496. Jul. 2023
  • Nicotinamide mononucleotide, a potential future therapy treatment in ocular diseases.
    Lee D, Tomita Y, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T†
    Graefes Arch Clin Exp Ophthalmol. Jun. 2023
  • Therapeutic roles of PPARα activation in ocular ischemic diseases
    Lee D*, Tomita Y*, Negishi K, Kurihara T†
    Histol Histopathol. 38(4) 391–401. Apr. 2023
  • Molecular and cellular regulations in the development of the choroidal circulation system
    Imanishi S, Tomita Y, Negishi K, Tsubota K†, Kurihara T†
    Int J Mol Sci. 24(6) 5371. Mar. 2023

和文

  • 近視進行の分子細胞生物学的メカニズム
    栗原俊英
    眼科 65(4) 359–365 2023年4月
  • 近視進行の分子細胞生物学的メカニズム
    栗原俊英
    眼科 65(4) 359–365 2023年4月
  • 近視のトランスレーショナルリサーチ
    栗原俊英
    Retina Medicine 12(1) 55-60 2023年4月

原著論文

英文

  • Deep-learning-based AI for evaluating estimated nonperfusion areas requiring further examination in ultra-widefield fundus images
    Inoda S, Takahashi H†, Yamagata H, Hisadome Y, Kondo Y, Tampo H, Sakamoto S, Katada Y, Kurihara T, Kawashima H, Yanagi Y
    Sci Rep.12(1):21826. Dec. 2022
  • Axl, Immune Checkpoint Molecules and HIF Inhibitors from the Culture Broth of Lepista luscina
    Kotajima M*, Choi JH*, Kondo M, D’Alessandro-Gabazza CN, Toda M, Yasuma T, Gabazza EC, Miwa Y, Shoda C, Lee D, Nakai A, Kurihara T, Wu J, Hirai H, Kawagishi H†
    Molecules. 27(24) 8925-8925. Dec. 2022
  • Nicotinamide Mononucleotide Protects against Retinal Dysfunction in a Murine Model of Carotid Artery Occlusion
    Lee D, Tomita Y, Miwa Y, Jeong H, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T†
    Intl J Mol Sci.23(23) 14711. Nov. 2022
  • Short-Term Exposure to Violet Light Emitted from Eyeglass Frames in Myopic Children: A Randomized Pilot Clinical Trial
    Torii H*†, Mori K*, Takashi Okano T, Kondo S, Yang HY, Yotsukura E, Hanyuda A, Ogawa M, Negishi K, Kurihara T†, Tsubota K†
    J Clin Med.11(20) 6000. Oct. 2022
  • Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes
    Ikeda SI, Kurihara T†, Jiang X, Miwa Y, Lee D, Serizawa N, Jeong H, Mori K, Katada Y, Kunimi H, Ozawa N, Shoda C, Ibuki M, Negishi K, Torii H, Tsubota K†
    Nat Commun. 13(1):5859. Oct. 2022
  • Nicotinamide Mononucleotide Prevents Retinal Dysfunction in a Mouse Model of Retinal Ischemia/Reperfusion Injury
    Lee D, Tomita Y, Miwa Y, Shinojima A, Ban N, Yamaguchi S, Nishioka K, Negishi K, Yoshino J, Kurihara T†
    Int J Mol Sci.23(19) 11228. Sep. 2022
  • Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenance
    Zhang Y*, Jeong H*, Mori K, Ikeda SI, Shoda C, Miwa Y, Nakai A, Chen J, Ma Z, Jiang X, Torii H, Kubota Y, Negishi K, Kurihara T†, Tsubota K†
    PNAS Nexus. pgac166. Aug. 2022
  • Automatic segmentation of non-perfusion area from fluorescein angiography using deep learning with uncertainty estimation
    Masayoshi K*, Katada Y*, Ozawa N, Ibuki M, Negishi K, Kurihara T†
    Inform Med Unlocked. 101060-101060. Aug. 2022
  • Retinal degeneration induced in a mouse model of ischemia–reperfusion injury and its management by pemafibrate treatment
    Lee D, Nakai A, Miwa Y, Tomita Y, Kunimi H, Chen J, Ikeda SI, Tsubota K, Negishi K, Kurihara T†
    FASEB J. 36(9):e22497. Aug. 2022
  • Children in Tokyo Have a Long Sustained Axial Length from Age 3 Years: The Tokyo Myopia Study.
    Maruyama T*, Yotsukura E*, Torii H*†, Mori K, Inokuchi M, Tokumura M, Hazra D, Ogawa M, Hanyuda A, Tsubota K, Kurihara T†, Negishi K†
    J Clin Med.11(15) 4413. Jul. 2022
  • Relation between Dry Eye and Myopia Based on Tear Film Breakup Time, Higher Order Aberration, Choroidal Thickness, and Axial Length.
    Hazra D*, Yotsukura E*, Torii H*†, Mori K, Maruyama T, Ogawa M, Hanyuda A, Tsubota K, Kurihara T†, Negishi K†
    Sci Rep.12(8) 10891. Jun. 2022
  • Lipidomic analysis revealed n‐3 polyunsaturated fatty acids suppressed choroidal thinning and myopia progression in mice.
    Mori K*, Kuroha S*, Hou J, Jeong H, Ogawa M, Ikeda SI, Kang JX, Negishi K, Torii H, Arita M†, Kurihara T†, Tsubota K
    FASEB J. 36(6) e22312. May. 2022
  • Non-Perfusion Area Index for Prognostic Prediction in Diabetic Retinopathy.
    Ofuji Y*, Katada Y*, Tomita Y, Nagai N, Sonobe H, Watanabe K, Shinoda H, Ozawa Y, Negishi K, Tsubota K, Kurihara T†
    Life. 12(4):542. Apr. 2022
  • Relationship of choroidal thickness and axial length with posterior vitreous detachment in patients with high myopia
    Hanyuda A*, Torii H*, Hayashi K, Uchida A, Mori K, Yotsukura E, Ogawa M, Negishi K, Kurihara T†, Tsubota T†
    Sci Rep.12(1):4093. Mar. 2022

原著総説

英文

  • Multiple Factors Causing Myopia and the Possible Treatments: A Mini Review.
    Shinojima A, Negishi K, Tsubota K, Kurihara T†
    Front Public Health. 10:897600. May. 2022
  • Ocular Ischemic Syndrome and Its Related Experimental Models.
    Lee D*, Tomita Y*, Yang L, Negishi K, Kurihara T†
    Int J Mol Sci.(9) 5249-5249. May. 2022
  • Degeneration of retinal ganglion cells in hypoxic responses: hypoxia-inducible factor inhibition, a new therapeutic insight.
    Lee D, Kunimi H, Negishi K, Kurihara T†
    Neural Regen Res. 17(10) 2730-2731. Feb. 2022

和文

  • 今月のサイエンス(5)
    栗原俊英
    慶應医学部新聞 (853) 2022年12月
  • 注目のイチオシ論文 : やさしく解説(第21回)オプトジェネティクスを応用した治療による視機能の部分的回復
    栗原俊英
    Retina Medicine 11(2) 145-148 2022年10月
  • 学童近視進行予防の現状
    栗原俊英
    医療情報誌アニムス (110) 11-16 2022年4月

原著論文

英文

  • Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion.
    Lee D, Nakai A, Miwa Y, Tomita Y, Serizawa N, Katada Y, Hatanaka Y, Tsubota K, Negishi K, Kurihara T†
    Biomed Res Int. 2021:7727648. Dec. 2021
  • Effect of Violet Light-Transmitting Eyeglasses on Axial Elongation in Myopic Children: A Randomized Controlled Trial.
    Mori K*, Torii H*, Hara Y, Hara M, Yotsukura E, Hanyuda A, Negishi K, Kurihara T†, Tsubota K†
    J Clin Med.10(22):5462. Nov. 2021
  • Glucose levels between the anterior chamber of the eye and blood are correlated based on blood glucose dynamics.
    Kurihara T*†, Lee D*, Shinojima A*, Kinoshita T, Nishizaki S, Arita Y, Hidaka Y, Nishi Y, Shirakawa Y, Kimura S, Tsuneyoshi Y, Torii H, Tsubota K, Negishi K†
    PLOS ONE. 16(9):e0256986. Sep. 2021
  • Shorter Axial Length Is a Risk Factor for Proliferative Vitreoretinopathy Grade C in Eyes Unmodified by Surgical Invasion.
    Minami S, Uchida A, Nagai N, Shinoda H, Kurihara T, Ban N, Terasaki H, Takagi H, Tsubota K, Sakamoto T, Ozawa Y†
    J Clin Med.10(17):3944. Aug. 2021
  • Pemafibrate Prevents Retinal Dysfunction in a Mouse Model of Unilateral Common Carotid Artery Occlusion.
    Lee D*, Tomita Y*, Jeong H, Miwa Y, Tsubota K, Negishi K, Kurihara T†
    Int J Mol Sci.22(17):9408-9408. Aug. 2021
  • Association between ocular axial length and anthropometrics of Asian adults.
    Shinojima A, Kurihara T†, Mori K, Iwai Y, Hanyuda A, Negishi K, Torii H, Tsubota K*
    BMC Res Notes. 14(1):328-328. Aug. 2021
  • Inhibition of the HIF-1α/BNIP3 pathway has a retinal neuroprotective effect.
    Kunimi H, Lee D, Ibuki M, Katada Y, Negishi K, Tsubota K, Kurihara T†.
    FASEB J. 35(8):e21829. Aug. 2021
  • Retinal dysfunction induced in a mouse model of unilateral common carotid artery occlusion.
    Lee D*, Jeong H*, Miwa Y, Shinojima A, Katada Y, Tsubota K†, Kurihara T†
    PeerJ. 9:e11665. Jun. 2021
  • Iris metastasis as the initial presentation of metastatic esophageal cancer diagnosed by fine needle aspiration biopsy: A case report.
    Ozawa H, Usui Y, Takano Y, Horiuchi N, Kuribayashi T, Kurihara T, Smith LEH, Tsubota K†, Tomita Y†
    Medicine. 100(22):e26232. Jun. 2021
  • Violet light suppresses lens-induced myopia via neuropsin (OPN5) in mice.
    Jiang X*, Pardue MT*, Mori K, Ikeda SI, Torii H, D’Souza S, Lang RA, Kurihara T†, Tsubota K†
    Proc Natl Acad Sci U S A. 118(22):e2018840118. Jun. 2021
  • Efficacy and safety of 0.01% atropine for prevention of childhood myopia in a 2-year randomized placebo-controlled study.
    Hieda O, Hiraoka T, Fujikado T, Ishiko S, Hasebe S, Torii H, Takahashi H, Nakamura Y, Sotozono C, Oshika T, Morimoto T, Nishida K, Nishikawa N, Song YS, Tokutake T, Nishi Y, Shigeno Y, Kurihara T, Negishi K, Tsubota K, Ono M, Nakai T, Tan D, Tanaka S, Kinoshita S†,
    Jpn J Ophthalmol.65(3):315-325. May. 2021
  • Long-term follow-up of a Chinese patient with KCNV2-retinopathy.
    Lie H*, Wang G*, Liu X*, Meng X, Long Y, Ren J, Yang L, Fujinami-Yokokawa Y, Kurihara T, Tsubota K, Fujinami K†, Li S†
    Ophthalmic Genet. 42(2):144-149. Apr. 2021
  • Assessment of Hypofluorescent Foci on Late-Phase Indocyanine Green Angiography in Central Serous Chorioretinopathy.
    Shinojima A*†, Ozawa Y*†, Uchida A, Nagai N, Shinoda H, Kurihara T, Suzuki M, Minami S, Negishi K, Tsubota K
    J. Clin. Med. 10(10):2178. May. 2021
  • Fenofibrate Protects against Retinal Dysfunction in a Murine Model of Common Carotid Artery Occlusion-Induced Ocular Ischemia.
    Lee D*, Tomita Y*, Miwa Y, Jeong H, Mori K, Tsubota K†, Kurihara T†
    Pharmaceuticals. 14(3):223 Mar. 2021
  • Spatial Functional Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake disease); EAOMD Report No.2.
    Yang L*, Joo K *, Tsunoda K, Kondo M, Fujinami-Yokokawa Y, Arno G, Pontikos N, Liu X, Nakamura N, Kurihara T, Tsubota K, Iwata T, Li H, Zou X, Wu S, Sun Z, Ahn SJ, Kim MS, Mun YS, Park KH, Robson AG, Miyake Y, Woo SJ, Sui R, Fujinami K†
    Am J Ophthalmol.221:169-180. Jan. 2021

原著総説

英文

  • Retinal Diseases Regulated by Hypoxia-Basic and Clinical Perspectives: A Comprehensive Review.
    Shinojima A, Lee D, Tsubota K, Negishi K, Kurihara T†
    J Clin Med.10(23) 5496. Nov. 2021
  • PPARα Modulation-Based Therapy in Central Nervous System Diseases.
    Lee D*, Tomita Y*, Allen W, Tsubota K, Negishi K, Kurihara T†
    Life. 11(11). Nov. 2021
  • Updates on the Current Treatments for Diabetic Retinopathy and Possibility of Future Oral Therapy.
    Tomita Y*, Lee D*, Tsubota K, Negishi K, Kurihara T†
    J Clin Med.10(20) 4666. Oct. 2021
  • HIF Inhibition Therapy in Ocular Diseases.
    Lee D*, Miwa Y*, Kunimi H, Ibuki M, Shoda C, Nakai A, Kurihara T†
    Keio J Med. Apr. 2021

和文

  • 目の働きはものを「見る」だけではない
    坪田一男、鳥居秀成、栗原俊英
    BRAIN and NERVE 73(11) 1185-1191 2021年11月
  • 糖尿病網膜症進展に関わる低酸素応答とその制御
    栗原俊英
    糖尿病合併症 35(2) 203 2021年8月
  • 低酸素応答制御に基づく網膜視神経疾患への創薬
    栗原俊英
    眼薬理 35(1) 59-62 2021年8月
  • 今月のサイエンス(4)
    栗原俊英
    慶應医学部新聞 (837) 2021年8月
  • オプトジェネティクスによる網膜変性疾患の視覚再建
    栗原俊英
    眼科臨床紀要 14(7) 421-423 2021年7月
  • 網膜橋渡し研究アップデート １１．光遺伝学療法
    栗原俊英
    眼科 63(2) 162-166 2021年2月
  • 基礎研究コラム44. 選択的PPARα作動薬の網膜疾患への有用性
    富田洋平、栗原俊英
    あたらしい眼科 38(1) 81 2021年1月
  • 屋外環境光による介入
    栗原俊英
    眼科 63(1): 17-22 2021年1月

原著論文

英文

  • Axial Length and Prevalence of Myopia among Schoolchildren in the Equatorial Region of Brazil.
    Yotsukura E*, Torii H*, Ozawa H*, Hida RY, Shiraishi T, Corso Teixeira I, Rautha YVBL, Moraes do, Nascimento CF, Mori K, Uchino M, Kurihara T†, Negishi K†, Tsubota K†
    J Clin Med. 10(1):115. Dec. 2020
  • Axial length shortening in a myopic child with anisometropic amblyopia after wearing violet light-transmitting eyeglasses for 2 years.
    Ofuji Y*, Torii H*, Yotsukura E, Mori K, Kurihara T, Negishi K, Tsubota K†
    Am J Ophthalmol Case Rep. 20:101002. Dec. 2020
  • Automatic screening for diabetic retinopathy in interracial fundus images using artificial intelligence.
    Katada Y*, Ozawa N*Masayoshi K, Ofuji Y, Tsubota K, Kurihara T†
    Intell Based Med. 100024. Dec. 2020
  • Oral Bovine Milk Lactoferrin Administration Suppressed Myopia Development through Matrix Metalloproteinase 2 in a Mouse Model.
    Ikeda SI*, Kurihara T†, Toda M, Jiang X, Torii H, Tsubota K†
    Nutrients. 12(12):3744. Dec. 2020
  • Efficacy of the Newly Invented Eyelid Clamper in Ultra-Widefield Fundus Imaging.
    Ozawa N*, Mori K*, Katada Y, Tsubota K†, Kurihara T†
    Life. 10(12):323. Dec. 2020
  • Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors.
    Ibuki M*, Lee D*, Shinojima A*, Miwa Y, Tsubota K†, Kurihara T†
    Int J Mol Sci. 21(23):8940-8940. Nov. 2020
  • A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion.
    Lee D*, Miwa Y*, Jeong H, Ikeda SI, Katada Y, Tsubota K†, Kurihara T†
    J Vis Exp. (165) doi: 10.3791/61865. Nov. 2020
  • Association between axial length and choroidal thickness in early age-related macular degeneration.
    Sato M, Minami S, Nagai N, Suzuki M, Kurihara T, Shinojima A, Sonobe H, Akino K, Ban N, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y†
    PLOS ONE. 15(10):e0240357. Oct. 2020
  • Risk of newly developing visual field defect and neurodegeneration after pars plana vitrectomy for idiopathic epiretinal membrane.
    Akino K*, Nagai N*, Watanabe K, Ban N, Kurihara T, Uchida A, Shinoda H, Tsubota K, Ozawa Y†
    Br J Ophtahlmol. 105 1683-1687. Oct. 2020
  • A Fairy Chemical Suppresses Retinal Angiogenesis as a HIF Inhibitor.
    Lee D*, Miwa Y*, Wu J, Shoda C, Jeong H, Kawagishi H, Tsubota K†, Kurihara T†
    Biomolecules. 10(10):1405. Oct. 2020
  • RP2-associated retinal disorder in a Japanese cohort:Report of novel variants and a literature review, identifying a genotype–phenotype association.
    Fujinami K†, Liu X, Ueno S, Mizota A, Shinoda K, Kuniyoshi K, Fujinami-Yokokawa Y, Yang L, Arno G, Pontikos N, Kameya S, Kominami T, Terasaki H, Sakuramoto H, Nakamura N, Kurihara T, Tsubota k, Miyake Y, Yoshiake K, Iwata T, Tsunoda K
    Am J Med Genet C Semin Med Genet. 184(3):675-693. Sep. 2020
  • Clinical and genetic characteristics of Stargardt disease in a large Western China cohort: Report 1.
    Liu X, Meng X, Yang L, Long Y, Fujinami‐Yokokawa Y, Ren J, Kurihara T, Tsubota K, Tsunoda K,Fujinami K, Li S
    Am J Med Genet C Semin Med Genet. 184(3):694-707. Sep. 2020
  • Clinical and genetic characteristics of 10 Japanese patients with PROM1-associated retinal disorder: A report of the phenotype spectrum and a literature review in the Japanese population.
    Fujinami K†, Oishi A, Yang L, Arno G, Pontikos N, Yoshitake K, Fujinami-Yokokawa Y, Liu X, Hayashi T, Katagiri S, Mizobuchi K, Mizota A, Shinoda K, Nakamura N, Kurihara T, Tsubota K, Miyake Y, Iwata T, Tsujikawa A, Tsunoda K
    Am J Med Genet C Semin Med Genet. 184(3):656-674. Sep. 2020
  • Pemafibrate Protects Against Retinal Dysfunction in a Murine Model of Diabetic Retinopathy.
    Tomita Y *, Lee D, Miwa Y, Jiang X, Ohta M, Tsubota K†, Kurihara T†
    Int. J. Mol. Sci. 21(17):6243. Aug. 2020.
  • Hyperreflective Material in Optical Coherence Tomography Images of Eyes with Myopic Choroidal Neovascularization May Affect the Visual Outcome.
    Mushiga Y, Minami S, Uchida A, Nagai N, Suzuki M, Kurihara T, Sonobe H, Ban N, Watanabe K, Shinoda H, Tsubota K, Ozawa Y†
    J Clin Med. 9(8):2394. Jul. 2020
  • Retinal microglia are critical for subretinal neovascular formation.
    Usui-Ouchi A, Usui Y, Kurihara T, Aguilar E, Dorrell MI, Fruttiger M, Ideguchi A, Sakimoto S, Bravo S, Kitano M, Friedlander M†
    JCI Insight. 5(12):e137317. Jun. 2020
  • Clinical and Genetic Characteristics of 18 Patients from 13 Japanese Families with CRX-associated retinal disorder: Identification of Genotype-phenotype Association.
    Fujinami-Yokokawa Y, Fujinami K*†, Kuniyoshi K, Hayashi T, Ueno S, Mizota A, Shinoda K, Arno G, Pontikos N, Yang L, Liu X, Sakuramoto H, Katagiri S, Mizobuchi K, Kominami T, Terasaki H, Nakamura N, Kameya S, Yoshitake K, Miyake Y, Kurihara T, Tsubota K, Miyata H, Iwata T, Tsunoda K
    Sci Rep. 10(1):9531. Jun. 2020
  • Clinical and Genetic Characteristics of 15 Affected Patients From 12 Japanese Families with GUCY2D-Associated Retinal Disorder.
    Liu X*, Fujinami K*, Kuniyoshi K, Kondo M, Ueno S, Hayashi T, Mochizuki K, Kameya S, Yang L, Fujinami-Yokokawa Y, Arno G, Pontikos N, Sakuramoto H, Kominami T, Terasaki H, Katagiri S, Mizobuchi K, Nakamura N, Yoshitake K, Miyake Y, Li S, Kurihara T, Tsubota K, Iwata T, Tsunoda K
    Transl Vis Sci Technol. 9(6):2-2. May. 2020
  • The Area and Number of Intraretinal Cystoid Spaces Predict the Visual Outcome after Ranibizumab Monotherapy in Diabetic Macular Edema.
    Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y†
    J Clin Med. 9(5):1391. May. 2020
  • Macular Pigment Optical Density and Photoreceptor Outer Segment Length as Predisease Biomarkers for Age-Related Macular Degeneration.
    Nagai N, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y†
    J Clin Med. 9(5):1347. May. 2020
  • Hypoxia-Inducible Factor Inhibitors Derived from Marine Products Suppress a Murine Model of Neovascular Retinopathy.
    Shoda C, Miwa Y, Nimura K, Okamoto K, Yamagami S, Tsubota K†, Kurihara T†
    Nutrients. 12(4):1055. Apr. 2020
  • Genetic Spectrum of EYS-associated Retinal Disease in a Large Japanese Cohort: Identification of Disease-associated Variants with Relatively High Allele Frequency.
    Yang L*, Fujinami K*†, Ueno S, Kuniyoshi K, Hayashi T, Kondo M, Mizota A, Naoi N, Shinoda K, Kameya S, Fujinami-Yokokawa Y, Liu X, Arno G, Pontikos N, Kominami T, Terasaki H, Sakuramoto H, Katagiri S, Mizobuchi K, Nakamura N, Mawatari G, Kurihara T, Tsubota K, Miyake Y, Yoshitake K, Iwata T, Tsunoda K
    Sci Rep. 10(1):5497-5497. Mar. 2020
  • Correlation between Macular Pigment Optical Density and Neural Thickness and Volume of the Retina.
    Nagai N, Asato T, Minami S, Suzuki M, Shinoda H, Kurihara T, Sonobe H, Watanabe K, Uchida A, Ban N, Tsubota K, Ozawa Y†
    Nutrients. 12(4):888-888. Mar. 2020
  • Closure of macular hole secondary to ischemic hemi-central retinal vein occlusion by retinal photocoagulation and topical anti-inflammatory treatment.
    Asato T, Nagai N, Suzuki M, Uchida A, Kurihara T, Ban N, Minami S, Shinoda H, Tsubota K, Ozawa Y†
    Lasers Med Sci. 36(2):469-471. Mar. 2021
  • Lactoferrin Has a Therapeutic Effect via HIF Inhibition in a Murine Model of Choroidal Neovascularization.
    Ibuki M, Shoda C, Miwa Y, Ishida A, Tsubota K†, Kurihara T†
    Front Pharmacol. 11:174-174. Feb. 2020
  • Relationship between nerve fiber layer defect and the presence of epiretinal membrane in a Japanese population: The JPHC-NEXT Eye Study.
    Uchida A, Sasaki M†, Motomura K, Yuki K, Kurihara T, Tomita Y, Ozawa Y, Yamagishi K†, Kawasaki R, Hanyuda A, Sawada N, Tsubota K, Tsugane S, Iso H
    Sci Rep. 10(1):779-779. Jan. 2020
  • Estimation of the minimum effective dose of dietary supplement crocetin for prevention of myopia progression in mice.
    Mori K, Kurihara T†, Jiang X, Ikeda SI, Yotsukura E, Torii H, Tsubota K†
    Nutrients. 12(1):180. Jan. 2020
  • Predicting recurrences of macular edema due to branch retinal vein occlusion during anti-vascular endothelial growth factor therapy.
    Suzuki M, Nagai N, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y†
    Graefes Arch Clin Exp Ophthalmol. 258(1):49-56. Jan. 2020

原著総説

英文

  • PPARα Agonist Oral Therapy in Diabetic Retinopathy.
    Tomita Y*, Lee D*, Tsubota K†, Kurihara T†
    Biomedicines. 8(10):433-433. Oct. 2020

和文

  • ブルーライトとスマートフォン
    栗原俊英
    OCULISTA 88:52-58 2020年7月
  • クロセチンの眼疾患に対する進行予防効果
    森紀和子、栗原俊英、坪田一男
    運動機能・認知機能改善食品の開発 314-322 2020年5月

原著論文

英文

  • Effect of axial length and age on the visual outcome of patients with idiopathic epiretinal membrane after pars plana vitrectomy.
    Minami S, Shinoda H, Shigeno Y, Nagai N, Kurihara T, Watanabe K, Sonobe H, Takagi H, Tsubota K, Ozawa Y†
    Sci Rep. 9(1):19056. Dec. 2019
  • Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults.
    Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Takagi H, Tsubota K, Ozawa Y†
    Sci Rep. 9(1):18119. Dec. 2019
  • The role of sphingosine 1-phosphate receptors on retinal pigment epithelial cells barrier function and angiogenic effects.
    Terao R, Honjo M, Totsuka K, Miwa Y, Kurihara T, Aihara M†
    Prostaglandins Other Lipid Mediat. 106365. Dec. 2019
  • Effects of Hyperoxia on the Refraction in Murine Neonatal and Adult Models.
    Mori K, Kurihara T†, Jiang X, Ikeda SI, Ishida A, Torii H, Tsubota K†
    Int J Mol Sci. 20(23):6014. Nov. 2019
  • Pemafibrate Prevents Retinal Pathological Neovascularization by Increasing FGF21 Level in a Murine Oxygen-Induced Retinopathy Model.
    Tomita Y*, Ozawa N*, Miwa Y, Ishida A, Ohta M, Tsubota K†, Kurihara T†
    Int J Mol Sci. 20(23):5878. Nov. 2019
  • Effect of midazolam, medetomidine, and butorphanol tartrate combination anesthetic on electroretinograms of mice.
    Miwa Y, Tsubota K†, Kurihara T†
    Mol Vis. 25:645-653. Oct. 2019
  • High Myopia and Its Associated Factors in JPHC-NEXT Eye Study: A Cross-Sectional Observational Study.
    Mori K, Kurihara T†, Uchino M, Torii H, Kawashima M, Sasaki M, Ozawa Y, Yamagishi K†, Iso H, Sawada N, Tsugane S, Yuki K, Tsubota K
    J Clin Med. 8(11):1788. Oct. 2019
  • Therapeutic Effect of Garcinia cambogia Extract and Hydroxycitric Acid Inhibiting Hypoxia-Inducible Factor in a Murine Model of Age-Related Macular Degeneration.
    Ibuki M, Shoda C, Miwa Y, Ishida A, Tsubota K†, Kurihara T†
    Int J Mol Sci. 20(20):5049. Oct. 2019
  • HIF inhibitor topotecan has a neuroprotective effect in a murine retinal ischemia-reperfusion model.
    Kunimi H, Miwa Y, Katada Y, Tsubota K†, Kurihara T†
    PeerJ. 7:e7849. Oct. 2019
  • Clinical and Genetic Characteristics of East Asian Patients with Occult Macular Dystrophy (Miyake Disease) East Asia Occult Macular Dystrophy Studies Report Number 1.
    Fujinami K*†, Yang L*, Joo K*, Tsunoda K, Kameya S, Hanazono G, Fujinami-Yokokawa Y, Arno G, Kondo M, Nakamura N, Kurihara T, Tsubota K, Zou X, Li H, Park KH, Iwata T, Miyake Y, Woo SJ†, Sui R†
    Ophthalmology. 126(10):1432-1444. Oct. 2019
  • The long dystrophin gene product Dp427 modulates retinal function and vascular morphology in response to age and retinal ischemia.
    Bucher F, Friedlander MSH, Aguilar E, Kurihara T, Krohne TU, Usui Y, Friedlander M†
    Neurochem Int. 129:104489. Oct. 2019
  • Pharmacological HIF inhibition prevents retinal neovascularization with improved visual function in a murine oxygen-induced retinopathy model.
    Miwa Y, Hoshino Y, Shoda C, Jiang X, Tsubota K†, Kurihara T†
    Neurochem Int. 128:21-31. Sep. 2019
  • Ultra-Widefield Retinal Imaging for Analyzing the Association Between Types of Pathological Myopia and Posterior Staphyloma.
    Mimura R*, Mori K*, Torii H, Nagai N, Suzuki M, Minami S, Ozawa Y, Kurihara T†, Tsubota K†
    J Clin Med. 8(10):1505. Sep. 2019
  • Current Prevalence of Myopia and Association of Myopia With Environmental Factors Among Schoolchildren in Japan.
    Yotsukura E*, Torii H*, Inokuchi M, Tokumura M, Uchino M, Nakamura K, Hyodo M, Mori K, Jiang X, Ikeda SI, Kondo S, Negishi K, Kurihara T†, Tsubota K†
    JAMA Ophthalmol. 137(11):1233-1239. Aug. 2019
  • The Effect of Dietary Supplementation of Crocetin for Myopia Control in Children: A Randomized Clinical Trial.
    Mori K*, Torii H*, Fujimoto S*, Jiang X, Ikeda SI, Yotsukura E, Koh S, Kurihara T†, Nishida K†, Tsubota K†
    J Clin Med. 8(8):1179. Aug. 2019
  • Dynamic changes in choroidal conditions during anti-vascular endothelial growth factor therapy in polypoidal choroidal vasculopathy.
    Nagai N, Suzuki M, Minami S, Kurihara T, Kamoshita M, Sonobe H, Watanabe K, Uchida A, Shinoda H, Tsubota K, Ozawa Y†
    Sci Rep. 9(1):11389. Aug. 2019
  • Ocular-Component-Specific miRNA Expression in a Murine Model of Lens-Induced Myopia.
    Tanaka Y, Kurihara T†, Hagiwara Y, Ikeda SI, Mori K, Jiang X, Torii H, Tsubota K†
    Int J Mol Sci. 20(15):3629. Jul. 2019
  • A Novel HIF Inhibitor Halofuginone Prevents Neurodegeneration in a Murine Model of Retinal Ischemia-Reperfusion.
    Kunimi H*, Miwa Y*, Inoue H, Tsubota K†, Kurihara T†
    Int J Mol Sci. 20(13):3171. Jun. 2019
  • Inducement and Evaluation of a Murine Model of Experimental Myopia.
    Jiang X, Kurihara T†, Ikeda SI, Kunimi H, Mori K, Torii H, Tsubota K†
    J Vis Exp. (143)e58822. Jan. 2019
  • QD laser eyewear as a visual field aid in a visual field defect model.
    Iyama C, Shigeno Y, Hirano E, Kamoshita M, Nagai N, Suzuki M, Minami S, Kurihara T, Sonobe H, Watanabe K, Shinoda H, Tsubota K, Ozawa Y†
    Sci Rep. 9(1):1010. Jan. 2019
  • Oral crocetin administration suppressed refractive shift and axial elongation in a murine model of lens-induced myopia.
    Mori K, Kurihara T†, Miyauchi M, Ishida A, Jiang X, Ikeda SI, Torii H, Tsubota K†
    Sci Rep. 9(1):295. Jan. 2019
  • Evaluation of AAV-DJ vector for retinal gene therapy.
    Katada Y, Kobayashi K, Tsubota K†, Kurihara T†
    PeerJ. 7:e6317. Jan. 2019

和文

  • 組織型プラスミノーゲンアクチベーター（tPA；モンテプラーゼ）硝子体内投与による黄斑下血腫の治療経過
    園部秀樹、篠田肇、鴨下衛、渡邊一弘、栗原俊英、永井紀博、坪田一男、小沢洋子
    あたらしい眼科 36(11) 104 - 108 2019年11月
  • 造血幹細胞移植後の新規ドライアイ発症例に近視化を伴った3症例
    伊藤賀一、小川葉子、清水映輔、鈴木孝典、西條裕美子、内野美樹、栗原俊英、坪田一男.
    あたらしい眼科 36(5):684-688 2019年 5月

原著総説

和文

  • 網膜疾患に対する遺伝子治療の現状と今後の可能性
    栗原俊英
    日本医事新報 (4988):56-57 2019年11月
  • 【医療×新ビジネス】《どこまで進む!?新技術の医療導入》
    大学発ベンチャーの挑戦 -CSV経営により社会の応援を得られるベンチャーをめざす-
    坪田一男、近藤眞一郎、早野元詞、小橋英長、堅田侑作、栗原俊英、明田直彦、羽藤晋
    Modern Physician. 39(7):659-662 2019年7月
  • 近視発生、進行の基礎概念
    栗原俊英
    診療で役立つ！近視進行予防のサイエンス 115-120 2019年4月
  • 近視のマウスモデル研究とこれまでの動物モデル研究
    姜効炎、栗原俊英
    診療で役立つ！近視進行予防のサイエンス 133-140 2019年4月
  • これからの近視抑制研究の方向性
    栗原俊英
    診療で役立つ！近視進行予防のサイエンス 158-160 2019年4月
  • 近視抑える「眼鏡・食品・コンタクト」の最新研究
    栗原俊英
    毎日新聞「医療プレミア」 2019年1月
  • 「1日2時間屋外活動」と目薬が近視を抑える可能性
    栗原俊英
    毎日新聞「医療プレミア」 2019年1月

原著論文

英文

  • Lactobacillus paracasei KW3110 Prevents Blue Light-Induced Inflammation and Degeneration in the Retina.
    Morita Y*†, Miwa Y*, Jounai K, Fujiwara D, Kurihara T, Kanauchi O
    Nutrients. 10(12):1991. Dec. 2018
  • A highly efficient murine model of experimental myopia.
    Jiang X, Kurihara T†, Kunimi H, Miyauchi M, Ikeda SI, Mori K, Tsubota K, Torii H, Tsubota K†
    Sci Rep. 8(1):2026. Feb. 2018
  • Benefits of aflibercept treatment for age-related macular degeneration patients with good best-corrected visual acuity at baseline.
    Minami S, Nagai N, Suzuki M, Kurihara T, Sonobe H, Kamoshita M, Uchida A, Shinoda H, Takagi H, Sonoda S, Sakamoto T, Tsubota K, Ozawa Y†
    Sci Rep. 8(1):58. Jan. 2018

原著総説

英文

  • Progress and Control of Myopia by Light Environments.
    Jiang X, Kurihara T†, Torii H, Tsubota K†
    Eye & Contact Lens. 44(5):273-278. Sep. 2018
  • Roles of hypoxia response in retinal development and pathophysiology
    Kurihara T†
    Keio J Med. 67(1):1-9. Mar. 2018

和文

  • 子どもの失明原因1位、増える「未熟児網膜症」
    栗原俊英
    毎日新聞「医療プレミア」 2018年12月
  • 網膜橋渡し研究アップデート：1．分子標的薬（抗血管新生療法）
    栗原俊英
    眼科 12(60):1513-1518 2018年11月
  • 視覚障害の原因2位、難病「網膜色素変性」とは
    栗原俊英
    毎日新聞「医療プレミア」2018年10月
  • あなたは大丈夫？失明の危険もある「病的近視」とは
    栗原俊英
    毎日新聞「医療プレミア」2018年8月
  • 突然の視力低下や視野障害 網膜血管閉塞症とは
    栗原俊英
    毎日新聞「医療プレミア」2018年4月
  • 紫色と近視と
    栗原俊英
    三田評論 (1219):107 2018年2月
  • 剥がれた網膜を戻す 治療最前線
    栗原俊英
    毎日新聞「医療プレミア」2018年1月

原著論文

英文

  • Elevated Aqueous Cytokine Levels in Eyes With Ocular Surface Diseases.
    Aketa N, Yamaguchi T†, Asato T, Yagi-Yaguchi Y, Suzuki T, Higa K, Kurihara T, Satake Y, Tsubota K, Shimazaki J
    Am J Ophthalmol. 184:42-51. Dec. 2017
  • Violet Light Transmission is Related to Myopia Progression in Adult High Myopia.
    Torii H, Ohnuma K, Kurihara T, Tsubota K, Negishi K†
    Sci Rep. 7(1):14523. Nov. 2017
  • Absolute and estimated values of macular pigment optical density in young and aged Asian participants with or without age-related macular degeneration.
    Ozawa Y*†, Shigeno Y*, Nagai N, Suzuki M, Kurihara T, Minami S, Hirano E, Shinoda H, Kobayashi S, Tsubota K
    BMC Ophthalmol. 17(1):161. Aug. 2017
  • Predictive factors of better outcomes by monotherapy of an antivascular endothelial growth factor drug, ranibizumab, for diabetic macular edema in clinical practice.
    Sato S, Shinoda H, Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Tomita Y, Iyama C, Minami S, Yuki K, Tsubota K, Ozawa Y†
    Medicine. 96(16):e6459. Apr. 2017

原著総説

和文

  • 低酸素応答 どうして新生血管は発生するのか　基礎研究コラム⑦
    栗原俊英
    あたらしい眼科 34(12):1749 2017年12月
  • 稲光やちりが見え、視野が狭まる…目に何が？
    栗原俊英
    毎日新聞「医療プレミア」2017年12月
  • JRPSもうまく基金賞　2016年度受賞者研究結果報告
    栗原俊英
    JRPSニュースレター 31:16-17 2017年11月
  • 「VEGFの網膜における生理的重要性」抗VEGF治療セミナー:46
    栗原俊英
    あたらしい眼科 34(11):1581-1582 2017年11月
  • 自覚症状なく進行 危険な糖尿病網膜症
    栗原俊英
    毎日新聞「医療プレミア」2017年10月
  • 【近視の進行をコントロールする】屋外環境とのかかわり
    鳥居秀成、栗原俊英、坪田一男
    眼科 59(9):897-903 2017年7月
  • 国内の失明原因4位　加齢黄斑変性とは
    栗原俊英
    毎日新聞「医療プレミア」2017年8月
  • “目の毒”と日々闘う網膜の仕組み
    栗原俊英
    毎日新聞「医療プレミア」2017年7月
  • 眼疾患とエピジェネティクス
    栗原俊英、坪田一男
    アンチ・エイジング医学－日本抗加齢医学会雑誌 12(6):770-775 2017年1月

原著論文

英文

  • Non-responsiveness to intravitreal aflibercept treatment in neovascular age-related macular degeneration: implications of serous pigment epithelial detachment.
    Nagai N, Suzuki M, Uchida A, Kurihara T, Kamoshita M, Minami S, Shinoda H, Tsubota K, Ozawa Y†
    Sci Rep. 6:29619. Jul. 2016
  • Distinct responsiveness to intravitreal ranibizumab therapy in polypoidal choroidal vasculopathy with single or multiple polyps.
    Suzuki M, Nagai N, Shinoda H, Uchida A, Kurihara T, Tomita Y, Kamoshita M, Iyama C, Tsubota K, Ozawa Y†
    Am J Ophthalmol. 166:52-59. Jun. 2016
  • Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration.
    Kurihara T*, Westenskow PD*, Gantner ML, Usui Y, Schultz A, Bravo S, Aguilar E, Wittgrove C, Friedlander MS, Paris LP, Chew E, Siuzdak G, Friedlander M†
    Elife. 5:e14319. Mar. 2016
  • Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression.
    Torii H, Kurihara T, Seko Y, Negishi K, Ohnuma K, Inaba T, Kawashima M, Jiang X, Kondo S, Miyauchi M, Miwa Y, Katada Y, Mori K, Kato K, Tsubota K, Goto H, Oda M, Hatori M, Tsubota K†
    EBioMedicine. 15:210-219. Feb. 2016
  • The Neuroprotective Effect of Rapamycin as a Modulator of the mTOR-NF-κB Axis during Retinal Inflammation.
    Okamoto T, Ozawa Y†, Kamoshita M, Osada H, Toda E, Kurihara T, Nagai N, Umezawa K, Tsubota K
    PLOS ONE. 11(1):e0146517. Jan. 2016
  • iPSC-Derived Retinal Pigment Epithelium Allografts Do Not Elicit Detrimental Effects in Rats: A Follow-Up Study
    Westenskow PD, Bucher F, Bravo S, Kurihara T, Feitelberg D, Paris LP, Aguilar E, Lin JH, Friedlander M†
    Stem Cells Int. 2016 Article ID 8470263. Jan. 2016
  • Global metabolomics reveals metabolic dysregulation in ischemic retinopathy.
    Paris LP*, Johnson C*, Aguilar E, Usui Y, Cho K, Hoang LT, Feitelberg D, Benton HP, Westenskow PD, Kurihara T, Trombley J, Tsubota K, Ueda S, Wakabayashi Y, Patti GJ, Ivanisevic J, Siuzdak G†, Friedlander M†
    Metabolomics. 12(1):15. Jan. 2016

和文

  • ルテイン高含有ホウレンソウ摂取による黄斑色素密度に対する効果のパイロットスタディ
    小沢洋子、永井紀博、鈴木美砂、栗原俊英、篠田肇、渡辺満、坪田一男
    日本眼科学会雑誌 120(1):41-48 2016年1月

原著総説

英文

  • Development and pathological changes of neurovascular unit regulated by hypoxia response in the retina
    Kurihara T†
    Prog Brain Res. 255:201-211. Apr. 2016

和文

  • アンチエイジング研究の最前線
    栗原俊英、坪田一男
    Medical Science Digest. 42(14):580-583 2016年12月
  • 『小児眼科Q&A』 I　学童近視、近視検査、屈折異常など.　14. 実験近視モデルの種類と特徴を教えてください
    栗原俊英
    あたらしい眼科 33(臨時増刊) 2016年11月
  • 2016年度研究助成＜もうまく基金賞＞を受賞して
    栗原俊英
    JRPS協会誌「あぁるぴぃ」(124):6 2016年9月
  • JRPSもうまく基金賞　2016年度研究助成受賞者実施計画　
    栗原俊英
    JRPSニュースレター 30:8-9 2016年9月
  • 北里賞を受賞して
    栗原俊英
    慶應医学部新聞 776 2016年6月
  • 網膜光毒性：現状評価と課題
    栗原俊英、石田晋
    ブルーライトテキストブック 34-39 2016年6月
  • 生涯学習のための眼科医レベルチェックテスト　「網膜硝子体疾患」
    栗原俊英
    眼科グラフィック 5(1):88-91 2016年1月

原著論文

英文

  • Wide-Angle Viewing System versus Conventional Indirect Ophthalmoscopy for Scleral Buckling.
    Tomita Y, Kurihara T, Uchida A, Nagai N, Shinoda H, Tsubota K, Ozawa Y†
    Sci Rep. 5:13256. Sep. 2015
  • Neurovascular crosstalk between interneurons and capillaries is required for vision.
    Usui Y*, Westenskow PD*, Kurihara T, Aguilar E, Sakimoto S, Paris LP, Wittgrove C, Feitelberg D, Friedlander MS, Moreno SK, Dorrell MI, Friedlander M†
    J Clin Invest. 125(6):2335-2346. Jun, 2015
  • Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo.
    Narimatsu T, Negishi K, Miyake S, Hirasawa M, Osada H, Kurihara T, Tsubota K, Ozawa Y†
    Exp Eye Res. 132:48-51. Mar. 2015
  • Performing subretinal injections in rodents to deliver retinal pigment epithelium cells in suspension.
    Westenskow PD†, Kurihara T, Bravo S, Feitelberg D, Sedillo ZA, Aguilar E, Friedlander M†
    J Vis Exp. (95)52247. Jan. 2015

原著総説

和文

  • 注目のイチオシ論文：やさしく解説（第7回）網膜において神経細胞はVEGF量を規定することにより血管新生を制限する
    栗原俊英
    Retina Medicine 4(2):160-164 2015年10月
  • 三四会奨励賞を受賞して
    栗原俊英
    慶應医学部新聞 (765) 2015年7月
  • 低酸素に制御される網膜 ―発生から病態生理まで―
    栗原俊英
    眼科 57(8):1027-1036 2015年7月
  • 第一次硝子体過形成遺残（PHPV）
    栗原俊英
    眼科 57(2):127-132 2015年2月