Dry eye group

Tear Film Health Science Team

Tear Film Health Science Team

Motoko Kawashima

メンバー: 佐野こころ、田邊裕貴、ヴ チ ホアン ビエト、松隈信一郎
Members: Kokoro Sano, Hirotaka Tanabe, Chi Hoang Viet Vu, Shinichiro Matsuguma

研究内容と目標 Research themes and objectives

 私たちは、様々なバックグラウンドを持ったメンバーでの新生ドライアイ基礎研究チームです。AgingをKey wordに、ドライアイ・マイボーム腺機能不全の発症メカニズムの解明および治療法の開発を目指しています。丁寧で根気強い実験の習得および、好奇心を大事にし、先入観にとらわれず、得られた結果をもとに自分で考えて進める力の育成を行いながら、常に臨床への還元を目標に成果を出せるよう研究を行っています。このため、眼科内外、学内外、国内外問わず、積極的に共同研究も進めています。前年度の成果をもとに(Sano K, et.al. IOVS, 2014)現在は、Environment enrichment/stress環境での涙液分泌変化とそのメカニズム解明に力を注いでいます。また、マイボーム腺機能不全の治療開発にも注力して遺伝子改変マウス及びmeibomian gland cell lineを用いて研究を進めています(Jin K, et.al. ARVO, 2014)

 We are a new research team conducting basic research in dry eye disease. Our members have a variety of research careers. We aim to elucidate mechanisms of dry eye disease and meibomian gland dysfunction and develop new treatment for these diseases from the aspect of aging. We are (1) keen to acquire excellent research skills, (2) curious about many things, (3) open to new ideas and (4) striving to develop original and independent thinking. We always hope to apply our research outcomes to clinical settings. Hence, we are highly active in teaming up with various researchers in the world. Based on our research article published last year (Sano K, et.al. IOVS, 2014), we are currently endeavoring to find out how tear secretion is affected by environmental enrichment or stress. We are also attempting to develop novel treatment for meibomian gland dysfunction using genetically modified mice and meibomian gland cell lines.

  1. Dry eye group

  2. Ocular Surface Immune Response Team


  3. Dry Eye and Oxidative Stress Research Team


  4. Mucins and Lipid Metabolites Research Team


  5. Dry Eye Related Environmental Stress Team


  6. Tear Film Health Science Team