Dry eye group

Ocular Surface Immune Response Team

眼表面免疫応答チーム
Ocular Surface Immune Response Team

サブチーフ
小川葉子

メンバー
河合正孝, 鴨居瑞加, 内野美樹, 立松由佳子, 西條裕美子, 谷口(寺田)紗織, 向井 慎, 福井正樹, 山根みお, 園部秀樹, 清水映輔, 浅井一樹, Jingliang He, Yan Fang

自己免疫疾患に伴うドライアイメカニズムの解明

 私達は、造血幹細胞移植後の慢性移植片対宿主病(Graft-versus-host disease;GVHD)およびシェーグレン症候群、スティーブンスジョンソン症候群、眼類天疱瘡やIg G4関連疾患などの自己免疫疾患に伴うドライアイに関する臨床と基礎研究を進めています。眼表面の共生細菌、涙液、涙腺、眼表面粘膜、マイボーム腺を含む前眼部病変について骨髄幹細胞動態、免疫応答、免疫老化、線維化の観点から分子メカニズムの検証を計画しています。

 

世界的ガイドラインの作成

 臨床では本グループのメンバーが本邦(Fukui M, Saijo Ban Y, Terada-Yaguchi S)および世界(DEWS II: Uchino M, Ogawa Y)のドライアイガイドライン作成を担当し進行中です。また、SeattleとChicagoにて眼GVHDの国際診断基準作成を目標に各国のGVHDの専門家とのdiscussionをすすめました(Shimizu E, Ogawa Y)。

MSCが免疫性線維化の原因であることを発見

 基礎研究からMHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model. の研究がeLife に掲載され、“間葉系幹細胞(MSC)が免疫性線維化の原因であることを発見-骨髄移植による重篤な合併症、GVHDの予防法につながる成果-”として報告されました。

GVHDの克服を目指して

 基礎研究ではマウスモデルを用いGVHDに対する新規治療法の開発を目指し日夜実験が行われています (①Mukai S. Sci Rep 2017 and AMED Seed A Grant, ②Fukui M. TFOS2016 Travel Grant, ③Yamane M. 学位履修審査終了④Sonobe H. 涙腺免疫応答検討)。皆で協力し、それぞれの研究分野と新しい概念を融合させ臨床の現場に還元できることを目指して前進できればと思います。

 We conduct basic and clinical research to elucidatemechanisms of dry eye disease and create new therapies.We are interested in the following types of dry eye disease:dry eye disease caused by immune-mediated diseases suchas Graft-versus-Host Disease (GVHD), Sjögren’s syndrome,Stevens-Johnson syndrome, ocular cicatricial pemphigoidand IgG4-related disease.We focus on microflora, tear fluid, lacrimal glands,ocular surface mucous membrane, and meibomian glands,since they are often impaired by immune-mediated dryeye disease, which affects stem cell dynamics and causesimmune mediated fibrosis.Most recently, we have published the research article,“MHC-compatible bone marrow stromal/stem cells triggerfibrosis by activating host T cells in a scleroderma mousemodel”in eLife. Our multicenter, prospective validationstudy to establish International Chronic Ocular GVHDconsensus diagnostic criteria is now underway.Several research projects in cGVHD-related dry eyedisease are ongoing. We now hope to further investigateimmune-mediated dry eye disease associated with stem cellaging, immune-mediated microbiome and fibrosis. We willstrive to make significant progress in GVHD research usingour sophisticated research skills and original thinking.

研究室の雰囲気をご紹介

English

We conduct basic and clinical research to elucidate mechanisms of dry eye disease and create new therapies. We are interested in the following types of dry eye disease: dry eye disease caused by immune-mediated diseases such as Graft-versus-Host Disease (GVHD), Sjögren’s syndrome, Stevens-Johnson syndrome, ocular cicatricial pemphigoid and IgG4-related disease.

We focus on microflora, tear fluid, lacrimal glands, ocular surface mucous membrane, and meibomian glands, since they are often impaired by immune-mediated dry eye disease, which affects stem cell dynamics and causes immune mediated fibrosis.

Most recently, we have published a research article about, “MHC-compatible bone marrow stromal/stem cells trigger fibrosis by activating host T cells in a scleroderma mouse model.” in eLife. Multicenter, prospective validation study to establish International Chronic Ocular GVHD consensus diagnostic criteria are now underway.

Several research projects in cGVHD-related dry eye disease are ongoing. We now hope to further investigate immune-mediated dry eye disease associated with stem cells aging, immune-mediated microbiome and fibrosis. We will strive to make significant progress in GVHD research using our sophisticated research skills and original thinking.  .

  1. Dry eye group

  2. Ocular Surface Immune Response Team

    眼表面免疫応答チーム

  3. Dry Eye and Oxidative Stress Research Team

    ドライアイと酸化ストレス研究チーム

  4. Mucins and Lipid Metabolites Research Team

    ムチン・脂質代謝チーム

  5. Dry Eye Related Environmental Stress Team

    ドライアイ-環境因子ストレスチーム

  6. Tear Film Health Science Team

    涙液層の健康科学チーム

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